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IF10.6!青岛大学借CHARLS 拿下双一区TOP!

  • 2026-02-15 12:19:51
IF10.6!青岛大学借CHARLS 拿下双一区TOP!

IF10.6!青岛大学借CHARLS 拿下双一区TOP！

今天分享一篇2025年3月10日由山东青岛大学在线发布于《Cholesterol, high-density lipoprotein, and glucose index versus triglyceride-glucose index in predicting cardiovascular disease risk: a cohort study》。本研究基于CHARLS数据库，通过多模型对比二者与CVD的关联及预测效能，为CVD风险分层提供新依据。

⭐研究设计及框架
基于CHARLS数据库6249名≥45岁无基线CVD参与者，随访9年，以CHG（新指数）与TyG（成熟指数）为核心暴露，通过多模型对比二者与CVD的关联及预测效能，构建 “指标计算-关联分析-效能对比-亚组验证” 框架，明确CHG的临床应用价值，为CVD风险分层提供新依据。

⭐可借鉴的研究要点
✅️创新对比：首次将CHG指数用于CVD风险预测，与成熟TyG指数头对头对比，填补新指数应用空白；
✅️验证全面：整合Cox、RCS、ROC等多模型，兼顾关联强度、关联形式与预测效能；
✅️适用广泛：亚组分析证实指标在不同人群中稳定，增强结果外推性；
✅️数据权威：依托全国代表性队列，大样本长随访提升证据可信度。

🚩关键研究方法
✅️数据源自CHARLS 2011-2020年数据，核心方法包括Cox比例风险回归量化关联、RCS分析关联形式、ROC曲线对比预测效能、亚组分析验证稳定性；
✅️按四分位分组分析指标与 CVD 的剂量反应，R 4.3.0 完成统计。

🌏主要研究结果
9年随访中1667人（26.68%）新发CVD。两种指数均与CVD风险显著正相关，CHG每升1单位风险升20%（HR=1.20），TyG每升1单位风险升8%（HR=1.08）；CHG呈线性关联，TyG呈非线性关联。ROC分析显示二者预测效能相当（AUC≈0.54-0.55），亚组分析证实关联不受性别、年龄、并发症等因素影响，稳定性良好。
如果你也想用CHARLS进行生信分析，复现高分思路，欢迎联系老马生信！#sci论文发表#sci论文#sci期刊#SCI期刊#医学SCI#文献检索#医学生笔记#生信分析#学术写作心得分享#科研人员的日常#科研成果分享#学术论文解读#期刊发表#期刊推荐

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  1. CONNECT:[ UseTime:0.000652s ] mysql:host=127.0.0.1;port=3306;dbname=g460;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.000882s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000327s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000251s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.000464s ]
  6. SELECT * FROM `set` [ RunTime:0.000192s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.000554s ]
  8. SELECT * FROM `article` WHERE `id` = 467055 LIMIT 1 [ RunTime:0.000578s ]
  9. UPDATE `article` SET `lasttime` = 1771233681 WHERE `id` = 467055 [ RunTime:0.012996s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 66 LIMIT 1 [ RunTime:0.004277s ]
  11. SELECT * FROM `article` WHERE `id` < 467055 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.003095s ]
  12. SELECT * FROM `article` WHERE `id` > 467055 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000436s ]
  13. SELECT * FROM `article` WHERE `id` < 467055 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.001016s ]
  14. SELECT * FROM `article` WHERE `id` < 467055 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.000933s ]
  15. SELECT * FROM `article` WHERE `id` < 467055 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.005400s ]
0.102827s